|
KMID : 0923620180180010001
|
|
Immune Network
2018 Volume.18 No. 1 p.1 ~ p.1
|
|
|
Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
|
|
Kim Chang-H.
|
|
|
Abstract
|
|
|
|
Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
|
|
|
KEYWORD
|
|
|
Retinoic acid, T-cells, B-cells, NK cells, Innate lymphoid cells
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|
|